Publikationen 2018
Fluconazole non-susceptible breakthrough candidemia after prolonged low-dose prophylaxis: a prospective FUNGINOS study Orasch C, Mertz D, Garbino J, van Delden C, Emonet S, Schrenzel J, Zimmerli S, Damonti L, Mühlethaler K, Imhof A, Ruef C, Fehr J, Zbinden R, Boggian K, Bruderer T, Flückiger U, Conen A, Khanna N, Frei R, Bregenzer T, Lamoth F, Erard V, Bochud PY, Calandra T, Bille J, Marchetti O, Fungal Infection Network of Switzerland (FUNGINOS) J Infect. 2018 Jan 26 [abstract] [Autors copy]
Osteoarticular and skin and soft-tissue infections caused by Streptococcus agalactiae in elderly patients are frequently associated with bacteremia Ruppen C, Notter J, Strahm C, Sonderegger B, Sendi P Diagn Microbiol Infect Dis. 2018 Jan;90(1):55-57. doi: 10.1016/j.diagmicrobio.2017.09.008. Epub 2017 Sep 19 [abstract] [Autors copy]
Clostridium difficile infection is associated with graft loss in solid organ transplant recipients Cusini A, Béguelin C, Stampf S, Boggian K, Garzoni C, Koller M, Manuel O, Meylan P, Mueller NJ, Hirsch HH, Weisser M, Berger C, van Delden C and the Swiss Transplant Cohort Study Am J Transplant. 2018 Jan 19. doi: 10.1111/ajt.14640 [abstract] [Autors copy]
Bone metabolism dynamics in the early post-transplant period following kidney and liver Transplantation Schreiber PW, Bischoff-Ferrari HA, Boggian K, Bonani M, van Delden C, Enriquez N, Fehr T, Garzoni C, Hirsch HH, Hirzel C, Manuel O, Meylan P, Saleh L, Weisser M, Mueller NJ and the Swiss Transplant Cohort Study (STCS) PLoS One. 2018 Jan 16;13(1):e0191167 [abstract] [full-text/pdf]
Correction to: Catheter retention as a consequence rather than a cause of unfavorable outcome in candidemia Damonti L, Erard V, Garbino J, Schrenzel J, Zimmerli S, Mühlethaler K, Imhof A, Zbinden R, Fehr J, Boggian K, Bruderer T, Flückiger U, Frei R, Orasch C, Conen A, Khanna N, Bregenzer T, Bille J, Lamoth F, Marchetti O, Bochud PY and the Fungal Infection Network of Switzerland (FUNGINOS) Intensive Care Med. 2018 Feb 20. doi [abstract] [full-text/pdf]
Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD41 T-Cell Decline, and Per-Parasite Pathogenicity Frederic Bertels, Alex Marzel, Gabriel Leventhal, Venelin Mitov, Jacques Fellay, Huldrych F. Günthard, Jürg Böni, Sabine Yerly, Thomas Klimkait, Vincent Aubert,Manuel Battegay, Andri Rauch, Matthias Cavassini, Alexandra Calmy, Enos Bernasconi, Patrick Schmid, Alexandra U. Scherrer, Viktor Müller, Sebastian Bonhoeffer, Roger Kouyos, Roland R. Regoes and the Swiss HIV Cohort Study Mol Biol Evol. 2018 Jan 1;35(1):27-37. doi [abstract] [full-text/pdf]
Hohe Inzidenz von Varizella- Zoster-Meningoenzephalitiden in Graubünden im Jahr 2014. Stocker A, Theus C, Boggian K, Mueller NJ, Fleisch F, Fehr T Praxis (Bern 1994). 2018;107(7):363-371 [abstract]
[full-text/pdf]
Infection Rate after Cranial Neurosurgical Procedures: A Prospective Single-Center Study Strahm C, Albrich WC, Zdravkovic V, Schöbi B, Hildebrandt G, Schlegel M World Neurosurg. 2018 Mar;111:e277-e285. doi: 10.1016/j.wneu.2017.12.062. Epub 2017 Dec 18 [abstract] [Autors copy]
LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions. Yu K, Davidson CL, Wójtowicz A, Lisboa L, Wang T, Airo AM, Villard J, Buratto J, Sandalova T, Achour A, Humar A, Boggian K, Cusini A, van Delden C, Egli A, Manuel O, Mueller N, Bochud PY and the Swiss Transplant Cohort Study, Burshtyn DN J Clin Invest. 2018 Apr 2;128(4):1523-1537
[abstract] [full-text/pdf]
Rapid decline of anti-hepatitis C virus (HCV) antibodies following early treatment of incident HCV infections in HIV-infected men who have sex with men Aebi-Popp K, Wandeler G, Salazar-Vizcaya L, Metzner K, Stöckle M, Cavassini M, Hoffmann M, Lüthi A, Suter F, Bernasconi E, Fehr J, Furrer H, Rauch A and the Swiss HIV Cohort Study HIV Med. 2018 Mar 24. doi: 10.1111/hiv.12602 [abstract] [Autors copy]
Epidemiology, risk factors and outcomes of invasive aspergillosis in solid organ transplant recipients in the Swiss Transplant Cohort Study Neofytos D, Chatzis O, Nasioudis D, Boely Janke E, Doco Lecompte T, Garzoni C, Berger C, Cussini A, Boggian K, Khanna N, Manuel O, Mueller NJ, van Delden C and the Swiss Transplant Cohort StudyTranspl Infect Dis. 2018 Apr 18:e12898. doi: 10.1111/tid.12898 [abstract] [Autors copy]
MRI and PET-CT Failed to Differentiate Between Hepatic Malignancy and Brucelloma Schreiber PW, Schmid A, Fagagnini S, Kröger A, Vrugt B, Reiner CS, Boggian K, Schiesser M, Müllhaupt B, Günthard HF Open Forum Infect Dis. 2018 Mar 8;5(4):ofy052. doi: 10.1093/ofid/ofy052 [abstract] [Autors copy]
Prediction of Bacteriuria based on Clinical or Laboratory Parameters in Patients with Indwelling Ureteral Stents prior to Ureterorenoscopy should not substitute for Urine Cultures Weber A, Zumstein V, Betschart P, Albrich WC, Nolte O, Engeler D, Schmid HP, Güsewell S, Abt D J Endourol. 2018 May 31. doi: 10.1089/end.2018.0256 [abstract] [Autors copy]
Accuracy of Sensititre YeastOne Echinocandins Epidemiological Cut-off Values for Identification of FKS mutant Candida albicans and Candida glabrata: A Ten Year National Survey of the Fungal Infection Network of Switzerland (FUNGINOS). Kritikos A, Neofytos D, Khanna N, Schreiber PW, Boggian K, Bille J, Schrenzel J, Mühlethaler K, Zbinden R, Bruderer T, Goldenberger D, Pfyffer G, Conen A, Van Delden C, Zimmerli S, Sanglard D, Bachmann D, Marchetti O, Lamoth F and the Fungal Infection Network of Switzerland (FUNGINOS) Clin Microbiol Infect. 2018 Jun 14. pii: S1198-743X(18)30445-2. doi: 10.1016/j.cmi.2018.05.012 [abstract] [Autors copy]
Toxoplasmosis in Transplant Recipients, Europe, 2010-2014 Robert-Gangneux F, Meroni V, Dupont D, Botterel F, Garcia JMA, Brenier-Pinchart MP, Accoceberry I, Akan H, Abbate I, Boggian K, Bruschi F, Carratalà J, David M, Drgona L, Djurković-Djaković O, Farinas MC, Genco F, Gkrania-Klotsas E, Groll AH, Guy E, Hirzel C, Khanna N, Kurt Ö, Junie LM, Lazzarotto T, Len O, Mueller NJ, Munoz P, Pana ZD, Roilides E, Stajner T, van Delden C, Villena I, Pelloux H, Manuel O Emerg Infect Dis. 2018 Aug;24(8):1497-1504. doi: 10.3201/eid2408.180045 [abstract] [Autors copy]
Is breastfeeding an equipoise option in effectively treated HIV-infected mothers in a high-income setting? Kahlert C, Aebi-Popp K, Bernasconi E, Martinez de Tejada B, Nadal D, Paioni P, Rudin C, Staehelin C, Wagner N, Vernazza P Swiss Med Wkly. 2018 Jul 24;148:w14648. doi: 10.4414/smw.2018.14648. eCollection 2018 [abstract] [Autors copy]
Impact of Direct-Acting Antivirals on the Burden of HCV Infection Among Persons Who Inject Drugs and Men Who Have Sex With Men in the Swiss HIV Cohort Study Salazar-Vizcaya L, Wandeler G, Fehr J, Braun D, Cavassini M, Stoeckle M, Bernasconi E, Hoffmann M, Rougemont M, Béguelin C, Rauch A and the Swiss HIV Cohort Study Open Forum Infect Dis. 2018 Jun 26;5(7):ofy154. doi: 10.1093/ofid/ofy154. eCollection 2018 Jul [abstract] [Autors copy]
Measles in Returning Adult Travelers Kositz C, Albrich WC Am J Trop Med Hyg. 2018 Jul;99(1):5-6. doi: 10.4269/ajtmh.18-0053 [abstract] [Autors copy]
Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study Schreiber PW, Bischoff-Ferrari HA, Boggian K, van Delden C, Enriquez N, Fehr T, Garzoni C, Hirsch HH, Hirzel C, Manuel O, Meylan P, Saleh L, Weisser M, Mueller NJ and the Swiss Transplant Cohort Study (STCS) Transpl Int. 2018 Aug 12 [abstract] [Autors copy]
High Cure Rates With Grazoprevir-Elbasvir With or Without Ribavirin Guided by Genotypic Resistance Testing Among Human Immunodeficiency Virus/Hepatitis C Virus-coinfected Men Who Have Sex With Men Braun DL, Hampel B, Kouyos R, Nguyen H, Shah C, Flepp M, Stöckle M, Conen A, Béguelin C, Künzler-Heule P, Nicca D, Schmid P, Delaloye J, Rougemont M, Bernasconi E, Rauch A, Günthard HF, Böni J, Fehr JS and the Swiss HIV Cohort Study Clin Infect Dis. 2018 Aug 13 [abstract] [Autors copy]
High Number of Potential Transmitters Revealed in a Population-based Systematic Hepatitis C Virus RNA Screening Among Human Immunodeficiency Virus-infected Men Who Have Sex With Men Braun DL, Hampel B, Martin E, Kouyos R, Kusejko K, Grube C, Flepp M, Stöckle M, Conen A, Béguelin C, Schmid P, Delaloye J, Rougemont M, Bernasconi E, Rauch A, Günthard HF, Böni J, Fehr JS and the Swiss HIV Cohort Study Clin Infect Dis. 2018 Aug 13 [abstract] [Autors copy]
Pneumocystis jirovecii pneumonia in solid organ transplant recipients: a descriptive analysis for the Swiss Transplant Cohort Neofytos D, Hirzel C, Boely E, Lecompte T, Khanna N, Mueller NJ, Boggian K, Cusini A, Manuel O, van Delden C and the Swiss Transplant Cohort Study Transpl Infect Dis. 2018 Aug 28:e12984.
doi: 10.1111/tid.12984 [abstract] [Autors copy]
Aortic Endograft Infection with Mycobacterium chimaera and Granulicatella adiacens, Switzerland, 2014 Plate A, Kohl TA, Keller PM, Majer S, Fulchini R, Strahm C, Medugno C, Rancic Z, Husmann L, Sax H, Niemann S, Hasse B Emerg Infect Dis. 2018 Sep;24(9):1700-1704. doi: 10.3201/eid2409.180247. Epub 2018 Sep 17 [abstract] [Autors copy]
Emergence of Carbapenemase-Producing Enterobacteriaceae, South-Central Ontario, Canada1 Kohler PP, Melano RG, Patel SN, Shafinaz S, Faheem A, Coleman BL, Green K, Armstrong I, Almohri H, Borgia S, Borgundvaag E, Johnstone J, Katz K, Lam F, Muller MP, Powis J, Poutanen SM, Richardson D, Rebbapragada A, Sarabia A, Simor A, McGeer A; Toronto Invasive Bacterial Diseases Network (TIBDN) Emerg Infect Dis. 2018 Sep;24(9):1674-1682. doi: 10.3201 [abstract] [Autors copy]
Antibiotic resistance in Swiss nursing homes: analysis of National Surveillance Data over an 11-year period between 2007 and 2017 Kohler P, Fulchini R, Albrich WC, Egli A, Balmelli C, Harbarth S, Héquet D, Kahlert CR, Kuster SP, Petignat C, Schlegel M, Kronenberg
Antimicrob Resist Infect Control. 2018 Jul 20;7:88. doi: 10.1186[abstract] [Autors copy]
Surveillance of sexualised drug use – the challenges and the opportunities Giraudon I, Schmidt AJ, Mohammed H
Int J Drug Policy. 2018 May;55:149-154. doi: 10.1016[abstract] [Autors copy]
Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity Kadelka C, Liechti T, Ebner H, Schanz M, Rusert P, Friedrich N, Stiegeler E, Braun DL, Huber M, Scherrer AU, Weber J, Uhr T, Kuster H, Misselwitz B, Cavassini M, Bernasconi E, Hoffmann M, Calmy A, Battegay M, Rauch A, Yerly S, Aubert V, Klimkait T, Böni J, Kouyos RD, Günthard HF, Trkola A and the Swiss HIV Cohort Study J Exp Med. 2018 Jun 4;215(6):1589-1608. doi[abstract] [Autors copy]
Quantifying the drivers of HIV transmission and prevention in men who have sex with men: a population model-based analysis in Switzerland Kusejko K, Marzel A, Hampel B1, Bachmann N, Nguyen H, Fehr J, Braun DL, Battegay M, Bernasconi E, Calmy A, Cavassini M, Hoffmann M, Böni J, Yerly S, Klimkait T, Perreau M9, Rauch A, Günthard HF, Kouyos RD and the Swiss HIV Cohort Study HIV Med. 2018 Jul 26. doi: 10.1111/hiv.12660[abstract] [Autors copy]
The Cumulative Impact of Harm Reduction on the Swiss HIV Epidemic: Cohort Study, Mathematical Model, and Phylogenetic Analysis Marzel A, Kusejko K, Weber R, Bruggmann P, Rauch A, Roth JA, Bernasconi E, Calmy A, Cavassini M, Hoffmann M, Böni J, Yerly S, Klimkait T, Perreau M, Günthard HF, Kouyos RD and the Swiss HIV Cohort Study Open Forum Infect Dis. 2018 May 19;5(5):ofy078. doi [abstract] [Autors copy]
Incidental Findings on Coronary Computed Tomography Angiography in Human Immunodeficiency Virus (HIV)-Positive and HIV-Negative Persons Reinschmidt S, Turk T, Tarr PE, Kouyos R, Hauser C, Schmid P, Weber R, Kaufmann P, Buechel RR, Kovari H and the Swiss HIV Cohort StudyStudy Open Forum Infect Dis. 2018 May 19;5(5):ofy078. doi [abstract] [Autors copy]
Long-term effectiveness of recommended boosted protease inhibitor-based antiretroviral therapy in Europe Santos JR, Cozzi-Lepri A, Phillips A, De Wit S, Pedersen C, Reiss P, Blaxhult A, Lazzarin A, Sluzhynska M, Orkin C, Duvivier C, Bogner J, Gargalianos-Kakolyris P, Schmid P, Hassoun G, Khromova I, Beniowski M, Hadziosmanovic V, Sedlacek D, Paredes R, Lundgren JD, EuroSIDA study group HIV Med. 2018 May;19(5):324-338. doi [abstract] [Autors copy]
No Effect of Pegylated Interferon-α on Total HIV-1 DNA Load in HIV-1/HCV Coinfected Patients Strouvelle VP, Braun DL, Vongrad V, Scherrer AU, Kok YL, Kouyos RD, Stöckle M, Rauch A, Darling K, Hoffmann M, Metzner KJ, Günthard HF, Zurich Primary HIV Infection Study and the Swiss HIV Cohort Study J Infect Dis. 2018 May 25;217(12):1883-1888. doi [abstract] [Autors copy]
Variation in antiretroviral treatment (ART) coverage and virological suppression among three HIV key populations Laut KG, Shepherd L, Gottfredsson M, Sedlacek D, Knysz B, Begovac J, Radoi R, Schmied B, Chkhartishvili N, Florence E, Ristola M, Fätkenheuer G, Mulcahy F, Schmid P, Kuzovatova E, Paduta D, Smidt J, Domingo P, Szlávik J, Lundgren J, Mocroft A, Kirk O and the EuroSIDA study Group AIDS. 2018 Oct 4. doi: 10.1097 [abstract] [Autors copy]
Inferring the age difference in HIV transmission pairs by applying phylogenetic methods on the HIV transmission network of the Swiss HIV Cohort Study Kusejko K, Kadelka C, Marzel A, Battegay M, Bernasconi E, Calmy A, Cavassini M, Hoffmann M, Böni J, Yerly S, Klimkait T, Perreau M, Rauch A, Günthard HF, Kouyos RD and the Swiss HIV Cohort Study Virus Evol. 2018 Sep 18;4(2):vey024. doi: 10.1093 [abstract] [Autors copy]
Population‐based outcome analysis of diffuse large B‐cell lymphoma in people living with HIV infection and competent individuals Conconi A, Zucca E, Margiotta-Casaluci G, Darling K, Hasse B, Battegay M, Staehelin C, Novak U, Schmid P, Scherrer A, Dirnhofer S, Kwee I, Nassi L, Cavalli F, Gaidano G, Bertoni F, Bernasconi E and the Swiss HIV Cohort study (SHCS) Hematol Oncol. 2018 Aug 16. doi: 10.1002 [abstract] [Autors copy]
Paritaprevir, ritonavir, ombitasvir, and dasabuvir with and without ribavirin in people with HCV genotype 1 and recent injecting drug use or receiving opioid substitution therapy Jason Grebely, Brian Conway, Evan B. Cunningham, Chris Fraser, Alberto Moriggia, Ed Gane, Catherine Stedman, Curtis Cooper, Erika Castro, Patrick Schmid, Kathy Petoumenos, Behzad Hajarizadeh, Phillipa Marks, Amanda Erratt, Olav Dalgard, Karine Lacombe, Jordan J. Feld, Julie Bruneau, Jean-Pierre Daulouede, Jeff Powis, Philip Bruggmann, Gail V. Matthews, Ian Kronborg, David Shaw, Adrian Dunlop, Margaret Hellard, Tanya L. Applegate, Sione Crawford, Gregory J Dore, on behalf of the D3FEAT Study Group Int J Drug Policy. 2018 Oct 29;62:94-103. doi: 10.1016 [abstract] [Autors copy]
Influence of biofilms on morbidity associated with short-term indwelling ureteral stents: a prospective observational study Betschart P, Zumstein V, Buhmann MT, Albrich WC, Nolte O, Güsewell S, Schmid HP, Ren Q, Abt D World J Urol. 2018 Nov 27. doi: 10.1007/s00345-018-2569 [abstract] [Autors copy]
Is breastfeeding an equipoise option in effectively treated HIV-infected mothers in a high-income setting? Kahlert C, Aebi-Popp K, Bernasconi E, Martinez de Tejada B, Nadal D, Paioni P, Rudin C, Staehelin C, Wagner N, Vernazza P Swiss Med Wkly. 2018 Jul 24;148:w14648. doi: 10.4414/smw.2018.14648 [abstract] [Autors copy]
Trends in HCV treatment uptake, efficacy and impact on liver fibrosis in the Swiss HIV Cohort Study Béguelin C, Suter A, Bernasconi E, Fehr J, Kovari H, Bucher HC, Stoeckle M, Cavassini M, Rougemont M, Schmid P, Wandeler G, Rauch A and the Swiss HIV Cohort Study Liver Int. 2018 Mar;38(3):424-431. doi: 10.1111 [abstract] [Autors copy]
Brain abscess caused by Cladophialophora bantiana: Total remission after full resection and short-course Voriconazole Treatment Schweizer LA, Bärlocher L, Graber A, Boggian K Med Mycol Case Rep. 2018 Dec 11;23:43-45. doi [abstract] [Autors copy]
Accuracy of Synovial Leukocyte and Polymorphonuclear Cell Count in Patients with Shoulder Prosthetic Joint Infection Strahm C, Zdravkovic V, Egidy C, Jost B K J Bone Jt Infect. 2018 Nov 11;3(5):245-248. doi: 10.7150/jbji.29289. eCollection 2018 [abstract] [Autors copy]
Bone metabolism dynamics in the early post-transplant period following kidney and liver Transplantation Schreiber PW, Bischoff-Ferrari HA, Boggian K, Bonani M, van Delden C, Enriquez N, Fehr T, Garzoni C, Hirsch HH, Hirzel C, Manuel O, Meylan P, Saleh L, Weisser M, Mueller NJ and Swiss Transplant Cohort Study (STCS) PLoS One. 2018 Jan 16;13(1):e0191167. doi: 10.1371/journal.pone.0191167. eCollection 2018 [abstract] [Autors copy]
Hand hygiene adherence in relation to influenza season during 6 consecutive years Fulchini R, Kohler P, Kahlert CR, Albrich WC, Kuhn R, Hoffmann M, Schlegel M Am J Infect Control. 2018 Nov;46(11):1311-1314. doi: 10.1016/j.ajic.2018.04.203. Epub 2018 May 18 [abstract] [Autors copy]
Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi’s sarcoma Bibert S, Wójtowicz A, Taffé P, Tarr PE, Bernasconi E, Furrer H, Günthard HF, Hoffmann M, Kaiser L, Osthoff M, Fellay J, Cavassini M, Bochud PY and the Swiss HIV Cohort Study AIDS. 2018 Nov 28;32(18):2759-2765. doi: 10.1097/QAD.0000000000002004 [abstract] [Autors copy]
Assessment of urinary 3-indoxyl sulfate as a marker for gut microbiota diversity and abundance of Clostridiales Farowski F, Els G, Tsakmaklis A, Higgins PG, Kahlert CR, Stein-Thoeringer CK, Bobardt JS, Dettmer-Wilde K, Oefner PJ, Vehreschild JJ, Vehreschild MJGT Gut Microbes. 2018 Aug 17:1-9. doi: 10.1080/19490976.2018.1502536 [abstract] [Autors copy]
Lipodystrophy Increases the Risk of CKD Development in HIV-Positive Patients in Switzerland: The LIPOKID Study Bouatou Y, Gayet Ageron A, Bernasconi E, Battegay M, Hoffmann M, Staehelin C, Merz L, Kovari H, Fux C, de Seigneux S, Calmy A and the Swiss HIV Cohort Study Kidney Int Rep. 2018 May 8;3(5):1089-1099. doi: 10.1016/j.ekir.2018.04.014. eCollection 2018 Sep [abstract] [Autors copy]
Neonatal Sepsis of Early Onset, and Hospital-Acquired and Community-Acquired Late Onset: A Prospective Population-Based Cohort Study Giannoni E, Agyeman PKA, Stocker M, Posfay-Barbe KM, Heininger U, Spycher BD, Bernhard-Stirnemann S, Niederer-Loher A, Kahlert CR, Donas A, Leone A, Hasters P, Relly C, Riedel T, Kuehni C, Aebi C, Berger C, Schlapbach LJ and the Swiss Pediatric Sepsis Study J Pediatr. 2018 Oct;201:106-114.e4. doi: 10.1016/j.jpeds.2018.05.048. Epub 2018 Jul 24 [abstract] [Autors copy]
Time-to-Positivity of Blood Cultures in Children With Sepsis Dierig A, Berger C, Agyeman PKA, Bernhard-Stirnemann S, Giannoni E, Stocker M, Posfay-Barbe KM, Niederer-Loher A, Kahlert CR, Donas A, Hasters P, Relly C, Riedel T, Aebi C, Schlapbach LJ, Heininger U and the Swiss Pediatric Sepsis Study Front Pediatr. 2018 Aug 8;6:222. doi: 10.3389/fped.2018.00222. eCollection 2018 [abstract] [Autors copy]
Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) Study Group in EuroCoord Clin Infect Dis. 2018 Feb 1;66(4):594-603. doi: 10.1093/cid/cix854 [abstract] [Autors copy]
Measles in Returning Adult Travelers Christian Kositz and Werner C. Albrich Am J Trop Med Hyg. 2018 Jul; 99(1): 5–6 [abstract] [full-text/pdf]
